עזרו לי להבין את ההגיון בקנאביס רפואי

[ArikM]

הבעיה הכי גדולה בקנאביס זה שאי אפשר לרשום עליו פטנט...אז מה עושים? 

מוציאים אותו מהחוק. פשוט מאד. 

אם היה אפשר להוציא על משהו ממנו פטנט, כבר מזמן היו כאן עשרות פיתוחים/נגזרות של החומר הפעיל

[David32]

Participants  Fifteen carefully selected long-term (>10 years) and heavy (>5 joints daily) cannabis-using men (mean age, 39.8 years; mean duration of regular use, 19.7 years) with no history of polydrug abuse or neurologic/mental disorder and 16 matched nonusing control subjects (mean age, 36.4 years).

 

 

The strongest evidence against the notion that cannabis is harmless comes from the animal literature^6-9 in which long-term cannabinoid administration has been shown to induce neurotoxic changes in the hippocampus, including decreases in neuronal volume, neuronal and synaptic density, and dendritic length of CA3 pyramidal neurons. Although such work suggests that exposure to cannabinoids may be neurotoxic in animals, much less is known about the neurobiologic consequences of long-term cannabis exposure in humans.

Only a handful of brain imaging studies have been conducted in human cannabis users, with inconsistent findings reported. Early cannabis research using pneumoencephalography¹⁰ reported cerebral atrophy in a small sample (N = 10) of cannabis users, but further studies using computed tomography^11-13 did not detect any abnormalities, despite the potential confounds of polydrug use, comorbid neurologic/psychiatric diagnoses, and a lack of appropriate comparison groups. More recent structural magnetic resonance imaging (MRI) studies have also reported contradictory findings, ranging from no global or regional changes in brain tissue volume or composition^14-16 to gray and white matter density changes, either globally¹⁷ or in focal regions, most notably in the hippocampal and parahippocampal areas.^18,19 However, these previous studies used imaging techniques with relatively coarse spatial and anatomical resolution and typically focused on samples with multiple substance use or comorbid psychiatric disorders and on only moderate levels of cannabis use (ie, <2 joints per day). Indeed, despite strong evidence of neurotoxicity in the animal literature,^6-9 to our knowledge, no neuroimaging study has examined the neurobiologic sequelae of long-term heavy cannabis use while controlling for the important confounds of polydrug abuse and co-occurring psychiatric disorders.

לפני 2 דקות, ArikM כתב:

אם היה אפשר להוציא על משהו ממנו פטנט, כבר מזמן היו כאן עשרות פיתוחים/נגזרות של החומר הפעיל

 

ויש, ויש מחקרים, ויש פטנטים על שיטות שימוש (למשל https://www.syqemedical.com/ הישראלית)

[fatboy1340]

https://www.nature.com/articles/npp201467

When comparing gray matter volume between groups, we find that significant clusters showing a lower gray matter volume in regular cannabis users compared with occasional ones are located bilaterally in the temporal pole and in the parahippocampal gyrus

 

Correlation analysis highlights an inverse linear correlation between GM volume and the monthly frequency of cannabis use during the 3 months before inclusion in the study

Recreational consumption begun early in adolescence (ie, ‘Occasional early’ subgroup) significantly affects the GM volume in two regions out of three. These are located in left parahippocampal gyrus (P=0.04) and right temporal pole (P=0.04); the left insula shows only a trend at P=0.09

[vadim6385]

לפני 8 שעות, ArikM כתב:

הבעיה הכי גדולה בקנאביס זה שאי אפשר לרשום עליו פטנט...אז מה עושים? 

מוציאים אותו מהחוק. פשוט מאד. 

 

הוציאו את זה מהחוק כדי לפגוע באפרו אמריקאים/היספאנים שזה מזוהה איתם.

 

ראש הDEA הראשון היה גזען ברמות, והוא זה שדחף להוציא את זה מחוץ לחוק קודם בארה"ב, ואז, כשהאו"ם הוציאו את אמנת הסמים הבינלאומית, בשאר העולם.

 

https://en.wikipedia.org/wiki/Harry_J._Anslinger